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HERO INGREDIENT

D-mannose that works where UTIs start

A pharmaceutical-grade simple sugar your body doesn't metabolize. It travels to the urinary tract unchanged and acts as a decoy, binding to E. coli before they can stick to your bladder wall.

500 mg
Pharmaceutical-grade d-mannose per dose
30 min
Rapid absorption and excretion into the bladder
Type 1 fimbriae
Targets Type 1 E. coli adhesion
90%
Excreted unchanged into urine, where it blocks bacterial attachment

THE SCIENCE

a sugar E.coli can't resist

D-mannose is a naturally occurring monosaccharide. Unlike glucose, your body doesn't metabolize it. It passes through the bloodstream and is excreted in urine largely unchanged, where it becomes available exactly where UTIs start. E. coli bacteria have tiny hair-like projections called Type 1 fimbriae that latch onto the urothelial wall. 

D-mannose binds to those fimbriae with far greater affinity than the bladder lining — so the bacteria grab the sugar instead, and get flushed out with urination.

E. coli latches onto d-mannose instead of you.
Dr. Meg, Good Kitty Cofounder
See the research
D-mannose for UTI prevention

D-mannose, a naturally occurring monosaccharide

Antibiotics WIPE OUT both GOOD & BAD bacteria

UTI Biome Shield® flushes E.coli without destroying your microbiome.

THE MECHANISM

How d-mannose clears E. coli from your bladder

A fast-acting decoy molecule is the first phase anti-adhesion in the bladder in UTI Biome Shield®.

01

Fast Acting

Rapidly absorbed and excreted unaltered into the bladder in as little as 30 minutes without affecting blood sugar. Predictable onset of action allows for dosing before intimacy.

02

Decoy

In the bladder Type 1 fimbriae of E. coli bind to d-mannose with high affinity — far more readily than to the bladder wall itself.

03

Flush

Bacteria coated in d-mannose molecules rather than your urothelium are flushed out with urination. No attachment means no infection.

How cranberry PACs work in the urinary tract

Based on randomized controlled trials of d-mannose in UTI prevention and treatment.

Based on randomized controlled trials of d-mannose in UTI prevention and treatment.

THE RESEARCH

Right dose. Right form. Great for protection before sex.

Clinically proven to reduce UTIs

60%UTI reduction

Clinical studies show d-mannose reduces recurrent UTI incidence vs placebo.

300+participants

Validated in randomized controlled trial against standard prophylactic care.

Dose determines effectiveness

500mgEach Capsule

Supports effective bacterial binding.

30 mintime to action

Fastest-acting UTI prevention ingredient in the formula.

Not all d-mannose is the same

GMPpharmaceutical-grade

Most supplements use food-grade d-mannose with inconsistent purity.

No fillerspure d-mannose

Some products cut d-mannose with glucose. Ours doesn't.

UTI Biome Shield® is antibiotic-free so it doesn't kill the good bacteria in your microbiome.

REAL RESULTS

From women who've tried everything

Verified customer reviews of UTI Biome Shield™.

Read all reviews
Sandra M.Verified Buyer

Amazing

After dealing with how miserable recurrent UTIs can be, I’m happy to have something proactive I can add to my routine instead of feeling like I’m always waiting for the next infection. Don’t hesitate, girl. Give it a try! 💕
Kelly L.Verified Buyer

Recurrent UTI Savior

After some research, I found this Good Kitty UTI Biome Shield and I am happy to report I have been UTI and discomfort free since starting and I am SO grateful this product exists! I will be recommending to anyone with the same problem.
Emily T.Verified Buyer

This stuff WORKS!!!!

Coming from someone who suffers from UTIs back to back and has tried EVERYTHING, I was skeptical about this product. It’s a MUST and has and still is helping me so much. You will NOT be disappointed!!!

UTI Biome Shield® Starter Kit

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Good Kitty UTI Biome Shield

FAQ

D-mannose questions, answered

Every order is covered by our 30-day risk-free guarantee.

D-mannose is a simple sugar, a close cousin of glucose, found in foods like cranberries, apples and peaches. Your body uses very little of it, so most of what you take passes into your urine, which is where it does its work.[5]

Most UTIs start when E. coli grabs the bladder wall with tiny hair-like fimbriae. The Type 1 fimbriae lock onto mannose on bladder cells. D-mannose in your urine acts as a decoy: bacteria latch onto it instead and get flushed out when you pee.[5]

The research is mixed. An early trial found fewer repeat UTIs with d-mannose than with no treatment.[1] Later reviews rated the evidence as low certainty,[2][4] and a 2024 trial of d-mannose alone found no reduction in repeat UTIs.[3] That is why UTI Biome Shield® pairs it with cranberry PACs instead of relying on d-mannose by itself.

Cranberry PACs have the stronger research base for daily protection.[6] D-mannose works on the Type 1 grip and gets to work quickly, which makes it useful around known triggers like sex.[5] UTI Biome Shield® combines 38 mg of cranberry PACs with 500 mg of d-mannose in one capsule.

Clinical trials of d-mannose on its own used 2 grams a day.[1][3] In UTI Biome Shield®, d-mannose works alongside cranberry PACs: one capsule daily gives you 500 mg, and two more before sex add 1,000 mg when you need it most, up to four capsules a day.

Take it before the moments that tend to set off a UTI, like sex. D-mannose acts fast but does not stay in your urine long, so timing matters more than taking a large amount all day.[5]

Yes. Studies report it is generally well tolerated. The most common side effect is loose stools, mostly at higher doses.[1][4]

Sources (7)
  1. Kranjčec B, Papeš D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014;32(1):79-84. doi.org/10.1007/s00345-013-1091-6
  2. Lenger SM, Bradley MS, Thomas DA, et al. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-13. doi.org/10.1016/j.ajog.2020.05.048
  3. Hayward G, Mort S, Hay AD, et al. d-Mannose for prevention of recurrent urinary tract infection among women: a randomized clinical trial. JAMA Intern Med. 2024;184(6):619-28. doi.org/10.1001/jamainternmed.2024.0264
  4. Cooper TE, Teng C, Howell M, et al. D-mannose for preventing and treating urinary tract infections. Cochrane Database Syst Rev. 2022;8:CD013608. doi.org/10.1002/14651858.CD013608.pub2
  5. Ala-Jaakkola R, Laitila A, Ouwehand AC, Lehtoranta L. Role of D-mannose in urinary tract infections: a narrative review. Nutr J. 2022;21(1):18. doi.org/10.1186/s12937-022-00769-x
  6. Williams G, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023;4:CD001321. doi.org/10.1002/14651858.CD001321.pub6
  7. Centers for Disease Control and Prevention. Urinary tract infection basics. www.cdc.gov/uti/

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.